Nppb

Expressed in the atria and ventricles throughout postnatal development and in adults.

Brain natriuretic peptide 45

Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:2525380, PubMed:9252368). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (By similarity). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (PubMed:2525380, PubMed:9252368).

The precursor molecule is proteolytically cleaved by the endoprotease Furin to produce brain natriuretic peptide 45 (PubMed:9252368). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Ser-91 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity).

Belongs to the natriuretic peptide family.

Expressed in the atria and ventricles, but at much lower levels than NPPA (PubMed:1837590). Expression levels in the ventricles are slightly higher than in the atria (PubMed:1837590). Very low levels of expression detected in the brain, hypothalamus, lung and aorta (PubMed:1837590).

Brain natriuretic peptide 45

Atria (at protein level) (PubMed:2673236). Cardiocytes (at protein level) (PubMed:9252368).

• Brain natriuretic peptide 45
• Secreted

Natriuretic peptides B, Brain natriuretic factor prohormone, Gamma-brain natriuretic peptide, Iso-ANP, preproBNP, proBNP, Nppb

• swissprot:P13205

Proteins

Cardiovascular