NPVF
Function
Neuropeptide RFRP-1
Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (PubMed:11025660, PubMed:20027225). Induces secretion of prolactin (By similarity).
Neuropeptide NPVF
Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia.
Neuropeptide RFRP-2
Shows no inhibitory activity of forskolin-induced production of cAMP.
Sequence Similarities
Belongs to the FARP (FMRFamide related peptide) family.
Tissue Specificity
Isoform 1
Specifically expressed in the retina.
Neuropeptide RFRP-1
Detected in the hypothalamus.
Neuropeptide NPVF
Detected in the hypothalamus.
Cellular localization
- Secreted
Alternative names
C7orf9, RFRP, NPVF, Pro-FMRFamide-related neuropeptide VF