NPY
GeneName
NPY
Summary
Neuropeptide Y (NPY), also known as hNPY, is an 11 kDa neuropeptide that plays a significant role in various physiological processes. It is primarily expressed in the central nervous system and is involved in the regulation of feeding behaviour, appetite, and energy homeostasis. NPY is secreted from neuronal dense core vesicles and acts on G protein-coupled receptors to mediate its effects. It is localised in the extracellular region, Golgi apparatus, and synaptic structures, and is implicated in chemical synaptic transmission and neuronal development, particularly in the cerebral cortex. NPY also has roles in modulating blood pressure and inflammatory responses, highlighting its diverse functional significance in neurobiology.
Importance
NPY is relevant to: - The regulation of appetite and feeding behaviour, making it a target for obesity research - Neurodevelopmental processes, particularly in the context of central nervous system disorders - The modulation of stress responses and anxiety through its influence on neurotransmitter systems - Cardiovascular health, as it is involved in blood pressure regulation and vascular function - Inflammatory conditions, given its role in the negative regulation of acute inflammatory responses
Top Products
For researchers investigating NPY, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Neuropeptide Y antibody (ab30914), which has garnered 91 citations and is particularly effective for immunohistochemistry (IHC). This product is widely trusted in the field for its performance. Additionally, we offer the recombinant antibody, Anti-Neuropeptide Y antibody [EPR21877] (ab221145), which is validated for both IHC and flow cytometry (FC). With 6 citations, this recombinant option provides the added benefit of batch-to-batch consistency, making it a reliable choice for your research needs.
Abcam Product Citation Summary
The data indicates that the Abcam antibody ab30914 is primarily used for detecting NPY in both immunohistochemistry and western blotting applications. The studies involve Tursiops truncatus and Rattus norvegicus, focusing on sympathetic neurohormones and heart tissue. This suggests a relevance of NPY in neurohormonal studies across different species.
Abcam Product Citation Table
Function
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Post-translational modifications
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Sequence Similarities
Belongs to the NPY family.
Tissue Specificity
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Cellular localization
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle
- Neuronal dense core vesicle
Alternative names
Pro-neuropeptide Y, NPY