NPY4R

Function

G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP (PubMed:7493937, PubMed:7592911). The rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

PPYR1, NPY4R, Neuropeptide Y receptor type 4, NPY4-R, Pancreatic polypeptide receptor 1, PP1

Database links

swissprot:P50391 omim:601790 entrezGene:5540 entrezGene:100996758