NR1I3
Domain
Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
Function
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Post-translational modifications
Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
Sequence Similarities
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Tissue Specificity
Predominantly expressed in liver.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Recruited to the cytoplasm by DNAJC7.
Alternative names
CAR, NR1I3, Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive androstane receptor, Orphan nuclear receptor MB67, Constitutive active response