TR4

Developmental stage

Transiently repressed during the meiotic phase of spermatogenesis.

Function

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Post-translational modifications

Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity).

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Cellular localization

• Nucleus

Alternative names

• Nuclear receptor subfamily 2 group C member 2
• Orphan nuclear receptor TAK1
• Orphan nuclear receptor TR4
• Testicular receptor 4
• NR2C2
• TAK1
• TR4

Database links

• entrezGene:7182
• omim:601426
• swissprot:P49116

Target type

Proteins

Molecular weight

65414Da