NRBP1
Domain
The protein kinase domain is predicted to be catalytically inactive.
Function
Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397).
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Tissue Specificity
Ubiquitously expressed in all tissues examined with high levels in the testis.
Cellular localization
- Cytoplasm
- Cell cortex
- Endomembrane system
- Cell projection
- Lamellipodium
- Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
Alternative names
BCON3, NRBP, NRBP1, Nuclear receptor-binding protein