NRDC
Function
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity).
Sequence Similarities
Belongs to the peptidase M16 family.
Tissue Specificity
Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
Cellular localization
- Mitochondrion
- Cell projection
- Dendrite
Alternative names
NRD1, NRDC, Nardilysin, N-arginine dibasic convertase, Nardilysin convertase, NRD convertase, NRD-C