NREP
Developmental stage
In embryos of gestational week (gw) 24, detected mostly in the epithelial cells of saccular surfaces. In gw 39, detected in the cells lining the alveolar surfaces as well as in the mesenchyme (at protein level).
Function
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
Post-translational modifications
Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.
Tissue Specificity
Expressed in lung (at protein level).
Cellular localization
- Cytoplasm
Alternative names
C5orf13, P311, NREP, Neuronal regeneration-related protein, Neuronal protein 3.1, Protein p311