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NRF1
Function
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Post-translational modifications
Phosphorylation enhances DNA binding.
Sequence similarities
Belongs to the NRF1/Ewg family.
Tissue specificity
Ubiquitously expressed with strongest expression in skeletal muscle.
Cellular localization
- Nucleus
Alternative names
- Nuclear respiratory factor 1
- NRF-1
- Alpha palindromic-binding protein
- Alpha-pal
- NRF1
Database links
Target type
Proteins
Primary research area
Epigenetics
Other research areas
- Immunology & Infectious Disease
Molecular weight
53541Da