NRF1

Function

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

Post-translational modifications

Phosphorylation enhances DNA binding.

Sequence Similarities

Belongs to the NRF1/Ewg family.

Tissue Specificity

Ubiquitously expressed with strongest expression in skeletal muscle.

Cellular localization

• Nucleus

Alternative names

Nuclear respiratory factor 1, NRF-1, Alpha palindromic-binding protein, Alpha-pal, NRF1

Database links

swissprot:Q16656 entrezGene:4899 omim:600879

Other research areas

• Immunology & Infectious Disease