NRF1

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

Phosphorylation enhances DNA binding.

Belongs to the NRF1/Ewg family.

Ubiquitously expressed with strongest expression in skeletal muscle.

• Nucleus

Nuclear respiratory factor 1, NRF-1, Alpha palindromic-binding protein, Alpha-pal, NRF1

• entrezGene:4899
• omim:600879
• swissprot:Q16656

Proteins

Epigenetics

• Immunology & Infectious Disease

53541Da