NRG3
Developmental stage
Isoform 3 is expressed in fetal brain but not in other fetal tissues.
Domain
The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
ERBB receptor binding is elicited entirely by the EGF-like domain.
Function
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Post-translational modifications
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
Sequence Similarities
Belongs to the neuregulin family.
Tissue Specificity
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Cellular localization
- Pro-neuregulin-3, membrane-bound isoform
- Cell membrane
- Single-pass type I membrane protein
- Does not seem to be active.
- Neuregulin-3
- Secreted
- Isoform 3
- Cell membrane
- Single-pass type I membrane protein
- Isoform 3 is also proteolytically released as a soluble form.
Alternative names
Pro-NRG3, NRG3