Nrp2
Developmental stage
The expression pattern is very dynamic and is developmentally regulated.
Domain
The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Function
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Sequence Similarities
Belongs to the neuropilin family.
Tissue Specificity
Expressed in developing CNS, PNS and in some nonneural tissues including limb buds, developing bones, muscles, intestinal epithelium, kidney, lung and submandibular gland.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Neuropilin-2, Vascular endothelial cell growth factor 165 receptor 2, Nrp2