NRP2
Domain
The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Function
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
Sequence Similarities
Belongs to the neuropilin family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Isoform s9
- Secreted
Alternative names
VEGF165R2, NRP2, Neuropilin-2, Vascular endothelial cell growth factor 165 receptor 2