NRXN3

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (By similarity).

Post-translational modifications

Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.

O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.

Sequence Similarities

Belongs to the neurexin family.

Tissue Specificity

Expressed in the blood vessel walls (at protein level).

Cellular localization

• Presynaptic cell membrane
• Single-pass type I membrane protein

Alternative names

KIAA0743, NRXN3, Neurexin-3-beta, Neurexin III-beta

Database links

swissprot:Q9HDB5 swissprot:Q9Y4C0 entrezGene:9369 omim:600567