NRXN3

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).

Post-translational modifications

O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.

Sequence Similarities

Belongs to the neurexin family.

Tissue Specificity

Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific.

Cellular localization

• Presynaptic cell membrane
• Single-pass type I membrane protein

Alternative names

C14orf60, KIAA0743, NRXN3, Neurexin-3, Neurexin III-alpha, Neurexin-3-alpha

Database links

swissprot:Q9Y4C0 entrezGene:9369 swissprot:Q9HDB5 omim:600567