NSR1
Function
Involved in pre-rRNA processing (PubMed:1644811). Specifically binds nuclear localization sequences (PubMed:1706724). Candidate for a receptor at the nucleus that may be involved in both RNA and protein transport (Probable). Binds telomeric sequences of the type (TG[1-3])n in vitro (PubMed:7800479).
Post-translational modifications
Methylated by HMT1, forming asymmetric dimethylarginines (DMA) within a domain referred to as an RGG box, made up of repeated Gly-Gly dipeptides interspersed with Arg and aromatic residues.
Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7) (PubMed:15604408). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:15604408, PubMed:17873058).
Sequence Similarities
Belongs to the RRM GAR family.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
Alternative names
YGR159C, G7001, NSR1, Nuclear localization sequence-binding protein, p67