NT5C
Function
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Sequence Similarities
Belongs to the 5'(3')-deoxyribonucleotidase family.
Tissue Specificity
Detected in skeletal muscle, heart and pancreas.
Cellular localization
- Cytoplasm
Alternative names
DNT1, UMPH2, NT5C, Deoxy-5'-nucleotidase 1, dNT-1