NT5C3B
Function
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).
Sequence Similarities
Belongs to the pyrimidine 5'-nucleotidase family.
Cellular localization
- Cytoplasm
Alternative names
NT5C3L, NT5C3B, 7-methylguanosine phosphate-specific 5'-nucleotidase, 7-methylguanosine nucleotidase, Cytosolic 5'-nucleotidase 3B, Cytosolic 5'-nucleotidase III-like protein, N(7)-methylguanylate 5'-phosphatase, cN-III-like protein