Nt5e
Function
Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:8224905). Hydrolyzes IMP (PubMed:8224905). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (By similarity). Although AMP is the preferred substrate can also hydrolyze UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (By similarity).
Sequence Similarities
Belongs to the 5'-nucleotidase family.
Tissue Specificity
Expressed at high levels in the placenta, kidney, lung and stomach and at lower levels in the thymus, spleen, skeletal muscle and esophagus.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
CD73, Nt5, Nte, Nt5e, 5'-nucleotidase, 5'-NT, 5'-deoxynucleotidase, Ecto-5'-nucleotidase, IMP-specific 5'-nucleotidase, Thymidylate 5'-phosphatase