NT5M
Function
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Sequence Similarities
Belongs to the 5'(3')-deoxyribonucleotidase family.
Tissue Specificity
Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas.
Cellular localization
- Mitochondrion
Alternative names
DNT2, NT5M, Deoxy-5'-nucleotidase 2, dNT-2