NTNG1
Domain
The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
Function
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Post-translational modifications
N-glycosylated.
Tissue Specificity
Highly expressed in the thalamus, with very low expression, if any, in other tissues.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Extracellular side
Alternative names
KIAA0976, LMNT1, UNQ571/PRO1133, NTNG1, Netrin-G1, Laminet-1