Nucb2
Domain
The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
Function
Calcium-binding protein which may have a role in calcium homeostasis (PubMed:10915798). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity).
Nesfatin-1
Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.
Sequence Similarities
Belongs to the nucleobindin family.
Tissue Specificity
Found in liver, heart, thymus, muscle, intestine, kidney, lung, spleen and throughout the brain, in cerebral cortex, hippocampus, hypothalamus and medulla oblongata. Nucb2 and necdin levels were higher in postmitotic neurons.
Cellular localization
- Cytoplasm
- Perikaryon
- Endoplasmic reticulum
- Golgi apparatus
- Nucleus envelope
- Membrane
- Peripheral membrane protein
- Secreted
- In dendrites and perikarya of brain neurons. Abundant in the ER cisternae and nuclear envelope, but not detected in Golgi, mitochondria or nucleoplasm in neurons. In cell culture, cytoplasmic and secreted.
- Nesfatin-1
- Secreted
Alternative names
Nefa, Nucleobindin-2, DNA-binding protein NEFA, Prepronesfatin