NUCKS1

Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318).

Phosphorylated in an ATM-dependent manner in response to DNA damage (PubMed:26323318). Phosphorylated by CDK1 and casein kinase (PubMed:11298763).

Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.

• Nucleus
• Chromosome

NUCKS, JC7, NUCKS1, Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, P1

• entrezGene:64710
• omim:611912
• swissprot:Q9H1E3

Proteins

27296Da