Nucleoside diphosphate kinase 7
Domain
Contains 2 putative kinase domains (94-224 and 239-372 AA), the first one is involved in autophosphorylation and the other may be inactive.
Function
Possesses an intrinsic kinase activity (PubMed:24807905). Displays 3'-5' exonuclease activity with a preference for single-stranded DNA (PubMed:16313181). Does not seem to have nucleoside diphosphate kinase activity (PubMed:16313181, PubMed:24807905). Functional component of the gamma-tubulin ring complex, implicated in the regulation of the microtubule-nucleating activity of the gamma-tubulin ring complex in centrosomes, in a kinase activity-dependent manner (PubMed:24807905). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189).
Post-translational modifications
Undergoes autophosphorylation.
Sequence Similarities
Belongs to the NDK family.
Tissue Specificity
Expressed in airway epithelial cells.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Nucleus
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Spindle
- Cytoplasm
- Cytoskeleton
- Cilium axoneme
- Cytoplasm
- Cytoskeleton
- Flagellum axoneme
- Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1.
Alternative names
Nucleoside diphosphate kinase homolog 7, NDK 7, NDP kinase homolog 7, 3'-5' exonuclease NME7, Protein kinase NME7, nm23-H7, NME7