NUDT10
Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Sequence Similarities
Belongs to the Nudix hydrolase family. DIPP subfamily.
Tissue Specificity
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.
Cellular localization
- Cytoplasm
Alternative names
APS2, DIPP3A, NUDT10, Diphosphoinositol polyphosphate phosphohydrolase 3-alpha, DIPP-3-alpha, DIPP3-alpha, hDIPP3alpha, Diadenosine hexaphosphate hydrolase (AMP-forming), Nucleoside diphosphate-linked moiety X motif 10, hAps2, Nudix motif 10