NUDT4
Function
Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).
Sequence Similarities
Belongs to the Nudix hydrolase family. DIPP subfamily.
Tissue Specificity
Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney.
Cellular localization
- Cytoplasm
Alternative names
DIPP2, KIAA0487, HDCMB47P, NUDT4, Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4