Numb

Developmental stage

Expressed in neural progenitors and neuron cells throughout the developing nervous system. Expressed in somites and throughout the neural tube from 8.5 dpc, onward.

Function

Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis (PubMed:10841580, PubMed:12410312, PubMed:15273690, PubMed:17174898). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (PubMed:12410312, PubMed:15273690). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis (PubMed:12410312, PubMed:15273690). Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (PubMed:17174898). May also mediate local repair of brain ventricular wall damage (PubMed:17174898).

Post-translational modifications

Phosphorylated on Ser-276 and Ser-295 by CaMK1.

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (By similarity) Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation.

Tissue Specificity

Expressed in subventricular zone (SVZ) neuroprogenitors and ependymal cells.

Cellular localization

• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Endosome membrane
• Peripheral membrane protein
• Cytoplasmic side
• Localizes to perinuclear endosomes in an AAK1-dependent manner.

Alternative names

Protein numb homolog, m-Nb, m-Numb, Numb

Database links

swissprot:Q9QZS3 entrezGene:18222

Other research areas

• Neuroscience