NUTF2

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

• Cytoplasm
• Cytosol
• Nucleus outer membrane
• Nucleus
• Nuclear pore complex
• Nucleus inner membrane
• Nucleus
• Nucleoplasm
• At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.

NTF2, NUTF2, Nuclear transport factor 2, NTF-2, Placental protein 15, PP15

• entrezGene:10204
• swissprot:P61970

Proteins

14478Da