NUTF2
Function
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
Cellular localization
- Cytoplasm
- Cytosol
- Nucleus outer membrane
- Nucleus
- Nuclear pore complex
- Nucleus inner membrane
- Nucleus
- Nucleoplasm
- At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
Alternative names
NTF2, NUTF2, Nuclear transport factor 2, NTF-2, Placental protein 15, PP15