NUTM1
Function
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
Involvement in disease
A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUTM1 fusion protein.
A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUTM1 fusion protein.
Post-translational modifications
Methylated at Gln-1046 by N6AMT1.
Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.
Sequence Similarities
Belongs to the NUT family.
Tissue Specificity
Specifically expressed in testis.
Cellular localization
- Cytoplasm
- Nucleus
- Shuttles between nucleus and cytoplasm.
Alternative names
C15orf55, NUT, NUTM1, NUT family member 1, Nuclear protein in testis