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Function

Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.

Involvement in disease

A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUTM1 fusion protein.

A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUTM1 fusion protein.

Post-translational modifications

Methylated at Gln-1046 by N6AMT1.

Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.

Sequence similarities

Belongs to the NUT family.

Tissue specificity

Specifically expressed in testis.

Cellular localization

  • Cytoplasm
  • Nucleus
  • Shuttles between nucleus and cytoplasm.

Alternative names

C15orf55, NUT, NUTM1, NUT family member 1, Nuclear protein in testis

Target type

Proteins

Primary research area

Oncology

Molecular weight

120314Da

We found 3 products in 1 category

Primary Antibodies

Target

Application

Reactive species

Search our catalogue for 'NUT' (3)

Products

ab315460

Anti-NUT antibody [EPR28221-46]

Recombinant
RabMAb
20ul selling size