The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction.
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.
(Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes.
Pseudo-TORCH syndrome 1
PTORCH1
An autosomal recessive neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.
None
The disease is caused by variants affecting the gene represented in this entry.
Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1.
Belongs to the ELL/occludin family.
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Proteins
Oncology
59144Da
We found 8 products in 3 categories
ab242202
ab254027
Neural Stem Cell Marker (Nestin, SOX2, Occludin, E Cadherin, Hes1, Notch1) Antibody Panel - Human
ab31721
ab222691
ab235986