ODAM
Function
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
Post-translational modifications
O-glycosylated.
Sequence Similarities
Belongs to the ODAM family.
Tissue Specificity
Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.
Cellular localization
- Secreted
- Cytoplasm
- Nucleus
Alternative names
APIN, ODAM, Odontogenic ameloblast-associated protein, Apin