Oga
Developmental stage
Expressed throughout development from blastocyst stage to embryonic day 16.5.
Function
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:16517082). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (By similarity). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:16517082). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (By similarity).
Post-translational modifications
Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
Sequence Similarities
Belongs to the glycosyl hydrolase 84 family.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
Hexc, Kiaa0679, Mgea5, Oga, Protein O-GlcNAcase, OGA, Beta-N-acetylhexosaminidase, Beta-hexosaminidase, Bifunctional protein NCOAT, Meningioma-expressed antigen 5, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase