Ogg1
Function
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Sequence Similarities
Belongs to the type-1 OGG1 family.
Tissue Specificity
Highest expression in testis.
Cellular localization
- Nucleus
- Nucleoplasm
- Nucleus speckle
- Nucleus matrix
- Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
Alternative names
N-glycosylase/DNA lyase, Ogg1