OGG1
Function
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Involvement in disease
Renal cell carcinoma
RCC
Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the type-1 OGG1 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
- Nucleoplasm
- Nucleus speckle
- Nucleus matrix
- Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
- Isoform 1A
- Nucleus
- Isoform 2A
- Mitochondrion
Alternative names
MMH, MUTM, OGH1, OGG1, N-glycosylase/DNA lyase