OLA1
Function
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Sequence Similarities
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
Tissue Specificity
Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
Cellular localization
- Cytoplasm
- Nucleus
- Nucleus
- Nucleolus
- Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.
Alternative names
GTPBP9, PRO2455, PTD004, OLA1, Obg-like ATPase 1, DNA damage-regulated overexpressed in cancer 45, GTP-binding protein 9, DOC45