OLIG1
Function
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
Tissue Specificity
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
Cellular localization
- Nucleus
Alternative names
BHLHB6, BHLHE21, OLIG1, Oligodendrocyte transcription factor 1, Oligo1, Class B basic helix-loop-helix protein 6, Class E basic helix-loop-helix protein 21, bHLHb6, bHLHe21