ompC
Domain
Loop L3 (residues 116-133) extends along the inner side of the beta barrel wall and may constrict the pore mid-length.
Function
Forms pores that allow passive diffusion of small molecules across the outer membrane.
(Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.
(Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity.
Sequence Similarities
Belongs to the Gram-negative porin family.
Cellular localization
- Cell outer membrane
- Multi-pass membrane protein
Alternative names
meoA, par, b2215, JW2203, ompC, Outer membrane porin C, Outer membrane protein 1B, Outer membrane protein C, Porin OmpC