OPALIN
Function
Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
Tissue Specificity
Brain specific; expressed in oligodendrocytes (PubMed:11814680, PubMed:30837646). Expressed in oligodendrocytes in remyelinating multiple sclerosis plaques (PubMed:30837646).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. Enriched in the leading edge of extending processes.
Alternative names
HTMP10, TMEM10, OPALIN, Opalin, Oligodendrocytic myelin paranodal and inner loop protein, Transmembrane protein 10