Oprd1
Function
G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Post-translational modifications
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Brain, with high concentrations in the basal ganglia and limbic regions.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Delta-type opioid receptor, D-OR-1, DOR-1, K56, MSL-2, Oprd1