ORF62
Function
Transcriptional transactivator. May interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. Negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis (By similarity).
Post-translational modifications
Phosphorylated by ORF66 protein kinase on Ser-686 and Ser-722. Also phosphorylated by ORF47 protein kinase and by human CSNK2A1/CKII (By similarity).
Sequence Similarities
Belongs to the herpesviridae ICP4 family.
Cellular localization
- Host nucleus
- Host cytoplasm
- Virion tegument
- Localizes to the cytoplasm when phosphorylated.
Alternative names
ORF71, ORF62, Major viral transcription factor ICP4 homolog, Immediate-early protein 62, IE62