ORF74
Function
Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1 (PubMed:29698475).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
- Host cell membrane
- Multi-pass membrane protein
Alternative names
viral G-protein coupled receptor, vGPCR, Protein ORF74, ORF74