OSBPL11
Developmental stage
During adipocyte differentiation, levels are elevated two-fold (at protein level).
Domain
The PH domain binds phosphoinositides.
Function
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).
Sequence Similarities
Belongs to the OSBP family.
Tissue Specificity
Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level) (PubMed:23028956).
Cellular localization
- Late endosome membrane
- Golgi apparatus
- trans-Golgi network membrane
- Localizes at the Golgi-late endosome interface.
Alternative names
ORP11, OSBP12, OSBPL11, Oxysterol-binding protein-related protein 11, ORP-11, OSBP-related protein 11