OSBPL1A
Domain
The FFAT motif is required for interaction with MOSPD2, VAPA and VAPB.
Function
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).
Sequence Similarities
Belongs to the OSBP family.
Cellular localization
- Late endosome
- Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
Alternative names
ORP1, OSBP8, OSBPL1, OSBPL1B, OSBPL1A, Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1