OSBPL6
Developmental stage
Expressed in fetal brain and lung.
Function
Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193).
Sequence Similarities
Belongs to the OSBP family.
Tissue Specificity
Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).
Cellular localization
- Cytoplasm
- Cytosol
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Nucleus envelope
- Cell membrane
- Peripheral membrane protein
- Endosome membrane
- Peripheral membrane protein
- Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum.
Alternative names
ORP6, OSBPL6, Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6