Osm
Function
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Post-translational modifications
Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
Sequence Similarities
Belongs to the LIF/OSM family.
Tissue Specificity
Widely expressed. Expressed at higher levels in liver, skin and spleen.
Cellular localization
- Secreted
Alternative names
Oncostatin-M, OSM, Osm