Osmr
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Function
Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM-specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration.
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Tissue Specificity
Widely expressed. Expressed at high levels in the liver, skin and spleen. In the liver it is expressed exclusively in the oval cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Osmrb, Osmr, Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB