OTUB2

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.

Belongs to the peptidase C65 family.

Widely expressed. Expressed at higher level in brain.

C14orf137, OTB2, OTU2, OTUB2, Ubiquitin thioesterase OTUB2, Deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain-2, Ubiquitin-specific-processing protease OTUB2

• entrezGene:78990
• omim:608338
• swissprot:Q96DC9

Proteins

Oncology

27213Da