OXGR1
Function
Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway.
Involvement in disease
Nephrolithiasis, calcium oxalate, 2, with nephrocalcinosis
CAON2
A form of nephrolithiasis, a condition in which urinary supersaturation leads to calcium oxalate stone formation in the urinary system. CAON2 is an autosomal dominant form often resultings in nephrocalcinosis.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Detected in kidney and, to a lower extent, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPR80, GPR99, P2RY15, P2Y15, OXGR1, 2-oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, G-protein coupled receptor 80, G-protein coupled receptor 99, P2Y purinoceptor 15, P2Y-like GPCR, P2Y-like nucleotide receptor