P2RX3_HUMAN
Domain
Contains extracellular allosteric binding sites-distinct from the orthosteric binding site.
Function
Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity).
Sequence Similarities
Belongs to the P2X receptor family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Localizes to neuronal cell body of sensory neurons.
Alternative names
P2X purinoceptor 3, P2X3, ATP receptor, Purinergic receptor, P2RX3