P2rx7
Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.
Post-translational modifications
Phosphorylation results in its inactivation.
ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.
Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
Sequence Similarities
Belongs to the P2X receptor family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
P2x7, P2rx7, P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor